the prognostic significance of her2-neu over expression in gastric carcinomas

نویسندگان

j ansari dept. of radiation oncology, aiatollah khoansari hospital, arak university of medical sciences, arak, iran

a chehrei dept. of pathology, amiralmoamenin hospital, arak university of medical sciences, arak, iran

m amini dept. of surgery, valiasr hospital, arak university of medical sciences, arak, iran

sh alizade dept. of surgery, valiasr hospital, arak university of medical sciences, arak, iran

چکیده

background: h e r2/ n eu i so n e o ftheepi de rmalg r owth f actor r e c e pt o rsfami l i e s andsee m stohaveprognosticsignificanceofsomesolid t umors.theo b jecti v eof thisstu d yistoevaluatet h epossi b ilityofher2ex p ressioningastricca n cersand the p o s si b le r e lat i o n ship o fh e r2withtumo r ’scli n icopat h o l o gicpara m e te r sa n d a l s oits pr o gno s tic r o l e .   methods: thisstudyw a s p e rfor m edon100cas e sofgas t r i ccarci n omaw i thstage ibto iii(acco r dingtotnms t aging). sur v i va l,rec u rrence d ateofpatients,gra d e and     lymph     nodes     in v o l v ement     were     assesse d .     her 2 /neu    ex p ression     was det e rmi n edbyimmunohis t oc h e micalmet h odonre c e i v eds a mpleb l ock s .s u rvival of patientswith orwit h outher 2 -neu expressionwere evalu a tedbykapla n -meier methodand c o mparedwiththelo g -ranktestfollo w edbymultiv a ria t eanalysis using cox regression.   results: sevencas e sw er e 3 +membra n o ush e r2 r e acti v i t y ,5ca s e s w e r e2+and 1 3 cas e s wer e 1+ ; a l s o 75 % o f ca s e s d e mo n stra t ed n oreacti v ity.regar d ing relations h ipbetweentumorgradeandmem br ano u sher2, allpatientswi t hpoorly differen t iated tumorswereher2ne g ative butpatientswithmoderate andwell differen t iated tumorhad18.1%and1 9 . 6 %her2reactivityr e s p ecti v e ly;t h ere were   no   significant   differe n ce   between   grou p s   s t atistically(p>0.05 ) .   median overalls u rviv a lwas27.25 a nd46monthsinher2negativeandher2positi v e cas e s    r e s p ect i ve l y ;    the r e    we r e    no    s i g n ificant    d i f f e re nce    betw e e n   groups statistic a l l y a s well ( p >0.05 ) .   conclusion: her2 reacti v ity h asnotrela t io n shipwithtumor gradeandly m phnode inv o lve m entaswellastumor stage.f r omtheoth e rp o intofviewno s i gnifica n t correlationisfound b e tween her2ex p ressionanddise a se frees u rvivaloro v er a ll survi v alof g a s t ric cancerpat i e nts.

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The Prognostic Significance of Her2-Neu Over expression in Gastric Carcinomas

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عنوان ژورنال:
iranian journal of cancer prevention

جلد ۴، شماره ۴، صفحات ۱۷۰-۱۷۶

کلمات کلیدی
[ ' g a s t r i c c a n c e r ' , ' a d e n o c a r c i n o m a ' , ' h e r 2 n e u p e p t i d e ' , ' s u r v i v a l a n a l y s i s p l e a s e c i t e t h i s a r t i c l e a s ' , ' a n s a r i j ' , ' c h e h r e i a ' , ' a m i n i m ' , ' a l i z a d e s h ' , ' s a n e i m h . t h e p r o g n o s t i c s i g n i f i c a n c e o f h e r 2 ' , ' n e u o v e r ' , ' e x p r e s s i o n i n g a s t r i c c a r c i n o m a s . i r a n j c a n c e r p r e v . 2 0 1 1 ' , ' v o l 4 ' , ' n o 4 ' , ' p 1 7 0 ' , ' 1 7 6 . r e f e r e n c e s 1 . k l a p p e r x a 0 l n ' , ' k i r c h b a u m x a 0 m h ' , ' s e l a x a 0 m ' , ' y a r d e n x a 0 y . b i o c h e m i c a l a n d c l i n i c a l i m p l i c a t i o n s o f t h e e r b b / h e r s i g n a l i n g n e t w o r k o f g r o w t h f a c t o r r e c e p t o r s . a d v . c a n c e r r e s . 2 0 0 0 ' , 7 7 , 2 5 , ' 7 9 . 2 . w o o d b u r n j r ' , ' t h e e p i d e r m a l g r o w t h f a c t o r r e c e p t o r a n d x a 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x a 0 s u r g i c a l x a 0 x a 0 o n c o l o g y x a 0 x a 0 2 0 0 3 ' , ' 1 0 ( 3 ) ' , 2 3 4 , ' 4 1 . 1 3 . l u i x a 0 v w ' , ' g r a n d i s x a 0 g r ' , ' e g f r ' , ' m e d i a t e d x a 0 c e l l x a 0 c y c l e r e g u l a t i o n . a n t i c a n c e r r e s 2 0 0 2 ' , ' 2 2 ( 1 a ) ' , 1 , ' 1 1 . 1 4 . l a u x a 0 m ' , ' l e x a 0 a ' , ' e l ' , ' s e r a g x a 0 h b . x a 0 n o n c a r d i a x a 0 g a s t r i c a d e n o c a r c i n o m a r e m a i n s a n i m p o r t a n t a n d d e a d l y c a n c e r i n x a 0 t h e x a 0 u n i t e d x a 0 s t a t e s ' , ' s e c u l a r x a 0 t r e n d s x a 0 i n x a 0 i n c i d e n c e x a 0 a n d s u r v i v a l . a m j g a s t r o e n t e r o l 2 0 0 6 ' , 1 0 1 , ' 2 4 8 5 . 2 4 9 2 ? . 1 5 . p e n g x a 0 j ' , ' w a n g x a 0 y . e p i d e m i o l o g y ' , ' p a t h o l o g y x a 0 a n d c l i n i c a l m a n a g e m e n t o f m u l t i p l e g a s t r i c c a n c e r s ' , ' a m i n i ' , ' r e v i e w . s u r g o n c o 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s t r i c c a n c e r ' , ' r a r e ' , ' h e t e r o g e n e o u s a n d o f n o p r o g n o s t i c v a l u e ' , ' c o n c l u s i o n s f r o m 9 2 4 c a s e s o f t w o i n d e p e n d e n t s e r i e s . c e l l o n c o l . 2 0 1 0 ' , ' 3 2 ( 1 ' , ' 2 ) ' , 5 7 , ' 6 5 . 1 9 . k a p t a i n s ' , ' t a n l k ' , ' c h e n b . h e r ' , ' 2 / n e u a n d b r e a s t c a n c e r . d i a g n m o l p a t h o l . 2 0 0 1 ' , 1 0 , 1 3 9 , ' 5 2 . 2 0 . s l a m o n d j ' , ' l e y l a n d x a 0 j o n e s b ' , ' s h a k s ' , ' f u c h s h ' , ' p a t o n v ' , ' b a j a m o n d e a ' , ' f l e m i n g t ' , ' e t a l . u s e o f c h e m o t h e r a p y p l u s x a 0 a x a 0 m o n x a 0 x a 0 o c l o n a l x a 0 a n t i b o d y x a 0 a g a i n s t x a 0 h e r x a 0 2 x a 0 f o r m e t a s t a t i c b r e a s t c a n c e r t h a t o v e r e x p r e s s e s h e r 2 . n . e n g l j . m e d . 2 0 0 1 ' , 3 4 4 , 7 8 3 , ' 9 2 . 2 1 . p r i t c h a r d k i ' , ' s h e p h e r d l e ' , ' 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' ]

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